it's not a signature with different picture going through and making the motions like that. That signature is made using the import movie into motion layers into PS I think.
It's like this SIG. I imported a movie into motion layers into photoshop:
Also if you are wanting to take ingame motions like that sig use FRAPS. That program takes in game movies of what you want in different games. Then all you do is save it in quicktime which then you can import that quicktime movie into photoshop.
If you really want to know how to do these let me know and I will point you to the right direction. I have done a few tutorials on a different site on how to import movies into photoshop and do video signature. ( it's too easy)
Hope this helps.
( the movie sigs are faster if only one on a post, but just wanted to show you they can be done)